Enzyme immunoassay for the quantitative determination of free Avelumab (Bavencio®) in serum and plasma
This kit has been especially developed for the quantitative determination of avelumab in serum and plasma samples between the Cmin and Cmax range of concentrations.
Avelumab Drug Bank Accession Number is DB11945.
Avelumab is a monoclonal antibody used to treat metastatic merkel cell carcinoma, metastatic urothelial carcinoma, or renal cell carcinoma. Avelumab binds PD-L1 through the FG loops 7 and blocks the interaction between PD-L1 and its receptors PD-1 and B7.1. This interaction releases the inhibitory effects of PD-L1 on the immune response resulting in the restoration of immune responses, including anti-tumor immune responses. Measurement of biological drug trough levels and antibody to biological drug gained high importance during the course of treatment. These measurements enable dose adjustments and switch to another class of biological drug when necessary.
All SHIKARI® ELISA kits are suitable for biosimilar work.
